Slc25a23 Gene Summary [Rat]
Predicted to enable ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and purine ribonucleotide transport. Predicted to act upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a23 |
| Official Name | solute carrier family 25 member 23 [Source:RGD Symbol;Acc:1588586] |
| Ensembl ID | ENSRNOG00000047781 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 23 |
| Synonyms | 2310067G05Rik, APC2, MCSC2, SCAMC3, solute carrier family 25 member 23, solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc25a23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- Mitochondrial carrier protein
- calcium ion binding
- EFh
- protein binding
- ADP transporter
- ATP transporter
- EF-hand domain
- adenine nucleotide transporter
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- transporter
- organophosphate:inorganic phosphate antiporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- Huntington disease
- cutaneous melanoma
- cutaneous melanoma cancer
regulates
- adenosine triphosphate
- Ca2+
- oxygen
- ADP
- AMP
role in cell
- cell viability
- cell death
- respiration in
- function
- accumulation in
- respiration by
- response by
- consumption in
- calcium loading capacity
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc25a23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
- elevation of mitochondrial calcium ion concentration
- regulation of oxidative phosphorylation
- regulation of cellular hyperosmotic salinity response
- regulation of sequestering of calcium ion
- ATP transport
- adenine nucleotide transport
- ADP transport
- mitochondrial calcium ion transport
- renal system process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- adenine nucleotide transmembrane transporter activity
- calcium ion binding
- ATP transmembrane transporter activity