Hspa8 Gene Summary [Rat]
Enables several functions, including A1 adenosine receptor binding activity; ATP hydrolysis activity; and adenyl ribonucleotide binding activity. Involved in several processes, including brain development; establishment of protein localization to organelle; and protein-containing complex disassembly. Acts upstream of or within protein-containing complex disassembly. Located in several cellular components, including dendrite; polymeric cytoskeletal fiber; and vacuole. Part of protein-containing complex. Is active in several cellular components, including glutamatergic synapse; glycinergic synapse; and postsynaptic density. Biomarker of Parkinson's disease; acute kidney failure; brain ischemia (multiple); disease of metabolism; and graft-versus-host disease. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa8 |
| Official Name | heat shock protein family A (Hsp70) member 8 [Source:RGD Symbol;Acc:621725] |
| Ensembl ID | ENSRNOG00000034066 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 8 |
| Synonyms | 2410008N15Rik, DnaK-type chaperone hsp72/uncoating ATPase, Heat Shock 70kD Protein 8, HEAT SHOCK COGNATE 71-KDA, HEAT SHOCK protein 8, heat shock protein family A (Hsp70) member 8, HEL-33, HEL-S-72p, HS7C, HSC54, HSC70, HSC71, Hsc73, HSP70, HSP70 7c, HSP71, HSP73, HSP7c, Hsp 8, HSPA10, IDBP1, LAP-1, LOC624853, NIP71, Stro-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspa8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- MreB/Mbl protein
- ATP-binding domain
- ADP binding
- Cell division protein FtsA
- G-protein-coupled receptor binding
- ATP binding
- heat shock protein binding
- protein binding activity, bridging
- enzyme
- ATPase
- ATPase domain
- chaperone binding
- Hsp70 protein
- ubiquitin protein ligase binding
- phospholipid binding
- lipid binding
- enzyme binding
- protein domain specific binding
- protein binding
- receptor binding
- RNA binding
- Fe-S protein assembly chaperone HscA
- binding protein
- chaperone protein DnaK
- receptor agonist activity
- substrate binding domain
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- Clathrin-mediated Endocytosis Signaling
- eNOS Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- Huntington's Disease Signaling
- Natural Killer Cell Signaling
- Protein Ubiquitination Pathway
- Role of PKR in Interferon Induction and Antiviral Response
- Unfolded protein response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- metastasis
- Huntington disease
- sickle cell anemia
- colorectal cancer
- epileptic seizure
- COVID-19
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
role in cell
- expression in
- degradation in
- cell death
- growth
- phosphorylation in
- formation in
- cell cycle progression
- apoptosis
- cell viability
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- nuclear fraction
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- polyribosome fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- lysosome matrix
- secretory granule lumen
- ficolin-1-rich granule lumen
- presynaptic regions
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubules
- intermediate filaments
- lipid droplets
- cytosol
- synaptic membrane
- lysosome membrane
- lysosomal compartment
- spliceosomes
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear scaffolds
- dendritic spines
- synaptic vesicles
- neurites
- synaptosomes
- synapse
- clastosomes
- photoreceptor inner segments
- autophagic vacuoles
- late endosomes
- secretory vesicles
- rough endoplasmatic reticulum
- microsomal membrane
- membrane rafts
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- inhibitory synapse
- ribbon synapse
- dendritic shafts
- exosomes
- clathrin-coated vesicles
- phagosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspa8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to progesterone stimulus
- positive regulation of proteolysis
- response to xenobiotic stimulus
- response to unfolded protein
- nuclear mRNA splicing, via spliceosome
- response to ethanol
- synaptic vesicle uncoating
- forebrain development
- cellular response to heat
- negative regulation of transcription, DNA-dependent
- positive regulation of nuclear mRNA splicing, via spliceosome
- kidney development
- G1/S transition of mitotic cell cycle
- cellular response to cadmium ion
- cellular response to hydrogen peroxide
- regulation of cell cycle
- membrane organization
- cerebellum development
- regulation of protein complex assembly
- chaperone mediated protein folding requiring cofactor
- cellular response to starvation
- protein folding
- protein refolding
- negative regulation of NLRP3 inflammasome complex assembly
- cellular response to steroid hormone stimulus
- regulation of protein stability
- positive regulation of lysosomal membrane permeability
- protein import into nucleus
- skeletal muscle tissue development
- ATP metabolic process
- response to estradiol stimulus
- positive regulation of T cell mediated cytotoxicity
- response to activity
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of phagocytosis
- response to nickel cation
- clathrin coat disassembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic vesicle
- late endosome
- lysosomal lumen
- Prp19 complex
- extracellular region
- nucleolus
- perikaryon
- autophagic vacuole
- microtubule
- nucleoplasm
- extracellular vesicular exosome
- focal adhesion
- terminal button
- dendritic shaft
- blood microparticle
- dendritic spine
- cytosol
- clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
- spliceosomal complex
- intermediate filament
- lysosomal membrane
- plasma membrane
- cell surface
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- melanosome
- cytoplasm
- membrane
- secretory granule lumen
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- heat shock protein binding
- C3HC4-type RING finger domain binding
- peptide binding
- unfolded protein binding
- ADP binding
- MHC class II protein complex binding
- G-protein coupled receptor binding
- ATP binding
- phosphatidylserine binding
- protein binding
- protein binding involved in protein folding
- ubiquitin protein ligase binding
- RNA binding
- cadherin binding
- chaperone binding
- protein binding, bridging
- A1 adenosine receptor binding
- enzyme binding