Tardbp Gene Summary [Rat]
Enables RNA binding activity. Involved in positive regulation of insulin secretion and response to endoplasmic reticulum stress. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tardbp |
| Official Name | TAR DNA binding protein [Source:RGD Symbol;Acc:1310906] |
| Ensembl ID | ENSRNOG00000012455 |
| Bio databases IDs | |
| Aliases | TAR DNA binding protein |
| Synonyms | 1190002A23Rik, AF311304, ALS10, Tadbp, TAR DNA binding protein, TAR DNA-binding protein-43, TDP-43 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tardbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine rich domain
- RNA recognition motif (RRM) superfamily
- transcription regulator
- lipid binding
- RNA recognition motif
- nucleic acid binding
- protein binding activity, bridging
- caspase cleavage site
- nuclear localization sequence
- protein binding
- ubiquitin-like domain
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA binding
- beta strand or sheet
- mRNA 3' UTR binding
- N-terminal domain of transactive response DNA-binding protein 43
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Tardbp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- paralysis
- weight loss
- gait disturbance
- motor dysfunction
- amyotrophic lateral sclerosis 10
- familial amyotrophic lateral sclerosis
- TARDBP -related frontotemporal dementia with TDP43 inclusions
- mild cognitive impairment
- Alexander disease
role in cell
- activation
- production in
- proliferation
- loss
- cytotoxicity
- number
- expression in
- upregulation in
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear chromatin
- organelle
- Cytoplasm
- vesicles
- Mitochondria
- granules
- cytosol
- interchromatin granules
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear speckles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tardbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- 3'-UTR-mediated mRNA stabilization
- positive regulation of protein import into nucleus
- RNA splicing
- 3'-UTR-mediated mRNA destabilization
- regulation of apoptotic process
- mRNA processing
- regulation of circadian rhythm
- negative regulation of gene expression
- regulation of protein stability
- rhythmic process
- negative regulation of protein phosphorylation
- nuclear inner membrane organization
- regulation of gene expression
- positive regulation of insulin secretion
- regulation of cell cycle
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- perichromatin fibrils
- nuclear speck
- mitochondrion
- intracellular non-membrane-bounded organelle
- interchromatin granule
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- pre-mRNA intronic binding
- identical protein binding
- protein binding
- RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- lipid binding
- mRNA 3'-UTR binding