XCL2
XCL2 Gene Summary
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | XCL2 |
| Official Name | X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10646] |
| Ensembl ID | ENSG00000143185 |
| Bio databases IDs | |
| Aliases | X-C motif chemokine ligand 2 |
| Synonyms | SCM-1b,SCYC2,X-C motif chemokine ligand 2 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the XCL2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCL5
- NR2F2
- CCL28
- NR2C2
- SPI1
- CXCL12
- NOTCH2NLA/NOTCH2NLB
- NFATC3
- HSF2
- CXCL5
disease
- colorectal cancer
- endometriosis
- diabetic nephropathy
- systemic lupus erythematosus
regulated by
- lipopolysaccharide
- IL4
- TGFB1
- IL2
- IL17F
- IL17A
- NOK cells
- PBMCs
regulates
- Ca2+
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the XCL2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- blood circulation
- positive regulation of GTPase activity
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- chemokine activity