CCL28 Gene Summary [Human]
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CCL28 |
| Official Name | C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] |
| Ensembl ID | ENSG00000151882 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 28, CC chemokine CCL28, mucosae-associated epithelial chemokine, small inducible cytokine subfamily A (Cys-Cys), member 28, small inducible cytokine A28 |
| Synonyms | CCK1, C-C motif chemokine ligand 28, MEC, SCYA28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCL28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL28 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- breast carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- primary sclerosing cholangitis
- dextran sodium sulfate-induced colitis
- alcoholic liver disease
- primary biliary cirrhosis
- gastric epithelial cancer
- airway hyperresponsiveness
role in cell
- migration
- accumulation
- number
- quantity
- binding
- killing
- chemotaxis
- adhesion
- recruitment
- viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- membrane surface
- Plasma Membrane
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCL28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- positive regulation of cell-matrix adhesion
- signal transduction
- response to nutrient
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemokine activity