Gt(ROSA)26Sor Gene Summary [Mouse]
This gene produces a long non-coding RNA (lncRNA) that is under the control of a constitutive promoter. This locus is a widely used site for the integration of transgenes and reporter constructs. [provided by RefSeq, Oct 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Gt(ROSA)26Sor |
| Official Name | gene trap ROSA 26, Philippe Soriano [Source:MGI Symbol;Acc:MGI:104735] |
| Ensembl ID | ENSMUSG00000086429 |
| Bio databases IDs | |
| Aliases | gene trap ROSA 26, Philippe Soriano |
| Synonyms | gene trap ROSA 26, Philippe Soriano, Gtrgeo26, Gtrosa26, Gt(ROSA)26Sor, HSALNG0024012, LOC100507618, LOC100509778, LOC100652926, NONHSAG085327, R26, ROSA26, SETD5-AS1, THUMPD3 antisense RNA 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- metabolic syndrome X
phenotypes
- abnormal posture
- decreased KLRG1-positive NK cell number
- decreased circulating cholesterol level
- decreased total body fat amount
- increased bone mineral content
- increased bone mineral density
- increased circulating alkaline phosphatase level
- abnormal anterior visceral endoderm cell migration
- abnormal axon morphology
- abnormal axonal transport
- abnormal basement membrane morphology
- abnormal blood vessel morphology
- abnormal body temperature
- abnormal bone marrow cell morphology/development
- abnormal bone ossification
- abnormal cell death
- abnormal cell physiology
- abnormal chemical nociception
- abnormal circulating lipid level
- abnormal coat/hair pigmentation
- abnormal cone electrophysiology
- abnormal corticospinal tract morphology
- abnormal defecation
- abnormal digestive system morphology
- abnormal double-strand DNA break repair
- abnormal ear pigmentation
- abnormal eating behavior
- abnormal embryonic hematopoiesis
- abnormal endocrine pancreas development
- abnormal enzyme/coenzyme activity
- abnormal epididymis epithelium morphology
- abnormal epididymis morphology
- abnormal erythropoiesis
- abnormal eye electrophysiology
- abnormal gait
- abnormal glucose homeostasis
- abnormal granulocyte differentiation
- abnormal heart left ventricle morphology
- abnormal hormone level
- abnormal humoral immune response
- abnormal keratinocyte differentiation
- abnormal kidney morphology
- abnormal lumbar vertebrae morphology
- abnormal mammary gland development
- abnormal mammary gland duct morphology
- abnormal medium spiny neuron morphology
- abnormal megakaryocyte morphology
- abnormal megakaryocyte progenitor cell morphology
- abnormal mesoderm development
- abnormal mitochondrial physiology
- abnormal mitochondrion morphology
- abnormal monocyte differentiation
- abnormal myocardial fiber morphology
- abnormal nervous system morphology
- abnormal neural tube closure
- abnormal neural tube morphology
- abnormal neuromuscular synapse morphology
- abnormal notochord morphology
- abnormal ocular fundus morphology
- abnormal optic nerve morphology
- abnormal pain threshold
- abnormal paraxial mesoderm morphology
- abnormal physiological response to xenobiotic
- abnormal placenta physiology
- abnormal platelet morphology
- abnormal podocyte slit diaphragm morphology
- abnormal proerythroblast morphology
- abnormal pulmonary artery morphology
- abnormal renal glomerulus morphology
- abnormal renal tubule morphology
- abnormal renal/urinary system morphology
- abnormal retinal blood vessel morphology
- abnormal retinal inner nuclear layer morphology
- abnormal retinal photoreceptor morphology
- abnormal retinal pigment epithelium morphology
- abnormal rod electrophysiology
- abnormal rostral-caudal axis patterning
- abnormal sarcomere morphology
- abnormal seminiferous tubule morphology
- abnormal skeletal muscle fiber morphology
- abnormal skeletal muscle regeneration
- abnormal skeleton morphology
- abnormal somite development
- abnormal spermatid morphology
- abnormal spinal cord morphology
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- abnormal synaptonemal complex
- abnormal tail development
- abnormal tail morphology
- abnormal vertebral column morphology
- abnormal vitelline vascular remodeling
- absent P wave
- absent allantois
- absent caudal vertebrae
- absent notochord
- albuminuria
- alopecia
- altered tumor pathology
- anal atresia
- anal stenosis
- anemia
- arrested B cell differentiation
- arrested T cell differentiation
- asthenozoospermia
- ataxia
- axon degeneration
- cachexia
- cardiac fibrosis
- cardiomyopathy
- caudal body truncation
- caudal vertebral transformation
- centrally nucleated skeletal muscle fibers
- cervical vertebral fusion
- cervical vertebral transformation
- choroidal neovascularization
- circling
- decreased B-1 B cell number
- decreased B-2 B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased adiponectin level
- decreased angiogenesis
- decreased anxiety-related response
- decreased birth body size
- decreased body size
- decreased body weight
- decreased bone resorption
- decreased bone trabecula number
- decreased cardiac muscle contractility
- decreased circulating LDL cholesterol level
- decreased circulating corticosterone level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating leptin level
- decreased epididymis weight
- decreased erythrocyte cell number
- decreased erythroid progenitor cell number
- decreased fatty acid beta-oxidation
- decreased grip strength
- decreased hematocrit
- decreased hemoglobin content
- decreased litter size
- decreased lymphocyte cell number
- decreased mammary gland epithelial cell proliferation
- decreased mature B cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular volume
- decreased myelin sheath thickness
- decreased neutrophil cell number
- decreased osteoclast cell number
- decreased paraxial mesoderm size
- decreased survivor rate
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased testis weight
- decreased thymocyte apoptosis
- decreased triglyceride level
- decreased trophoblast giant cell number
- decreased tumor latency
- decreased ventricle muscle contractility
- decreased vertical activity
- dilated heart left ventricle
- disorganized mitochondrial cristae
- disorganized retinal layers
- dorsal root ganglion degeneration
- dystrophic muscle
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- enlarged lymph nodes
- enlarged popliteal lymph nodes
- enlarged spleen
- epididymal inflammation
- epididymis fibrosis
- epididymis hypertrophy
- extramedullary hematopoiesis
- gastrointestinal hemorrhage
- gliosis
- glomerulosclerosis
- hairpin sperm flagellum
- hyperglycemia
- hypoactivity
- hypospadia
- impaired coordination
- impaired glucose tolerance
- impaired mammary gland growth during pregnancy
- impaired skeletal muscle contractility
- impaired somite development
- impaired wound healing
- increased B cell apoptosis
- increased abdominal fat pad weight
- increased apoptosis
- increased body weight
- increased bone mass
- increased bone stiffness
- increased bone strength
- increased bone trabecular spacing
- increased bone volume
- increased cell proliferation
- increased circulating HDL cholesterol level
- increased circulating erythropoietin level
- increased circulating free fatty acid level
- increased circulating insulin level
- increased circulating interleukin-1 alpha level
- increased circulating interleukin-1 beta level
- increased circulating iron level
- increased circulating leptin level
- increased circulating thyroxine level
- increased circulating triglyceride level
- increased circulating triiodothyronine level
- increased circulating tumor necrosis factor level
- increased compact bone thickness
- increased energy expenditure
- increased epididymal cell proliferation
- increased epididymal epithelium cell proliferation
- increased erythroid progenitor cell number
- increased food intake
- increased germinal center B cell number
- increased granulocyte number
- increased heart iron level
- increased hematopoietic stem cell number
- increased hematopoietic stem cell proliferation
- increased incidence of tumors by chemical induction
- increased inflammatory response
- increased interleukin-17 secretion
- increased intestinal iron level
- increased lean body mass
- increased leukocyte cell number
- increased liver iron level
- increased mean corpuscular hemoglobin
- increased mean corpuscular volume
- increased mean platelet volume
- increased megakaryocyte cell number
- increased mitochondria number
- increased mitochondria size
- increased mitochondrial fission
- increased neuronal precursor cell number
- increased osteoblast cell number
- increased oxygen consumption
- increased pancreatic islet number
- increased rib number
- increased spleen iron level
- increased susceptibility to Coronaviridae infection
- increased susceptibility to diet-induced obesity
- increased susceptibility to injury
- increased thermal nociceptive threshold
- increased total body fat amount
- increased trophoblast giant cell number
- insulin resistance
- intestine polyps
- kidney cysts
- kinked neural tube
- limb grasping
- lipofuscinosis
- lumbar vertebral transformation
- male infertility
- microvesicular hepatic steatosis
- neonatal lethality complete penetrance
- nervous system inclusion bodies
- no abnormal phenotype detected
- notochord degeneration
- oligozoospermia
- pallor
- perinatal lethality incomplete penetrance
- podocyte foot process effacement
- postnatal growth retardation
- premature death
- prenatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- preputial gland inflammation
- preweaning lethality complete penetrance
- prolonged QT interval
- rectal atresia
- rectal prolapse
- rectourethral fistula
- reduced female fertility
- reduced fertility
- renal tubule atrophy
- respiratory distress
- reticulocytosis
- retinal degeneration
- retinal outer nuclear layer degeneration
- retinal photoreceptor degeneration
- short frontal bone
- short nasal bone
- short snout
- short stride length
- skeletal muscle endomysial fibrosis
- skeletal muscle necrosis
- skin inflammation
- small lymph nodes
- small sacral vertebrae
- spermatocele
- spina bifida occulta
- testis degeneration
- thoracic vertebral transformation
- transmission ratio distortion
- tremors
- truncated notochord
- vascular smooth muscle hypoplasia
- vertebral transformation
- vestigial tail
- weight loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown