Stat6 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gene expression; interleukin-4-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; gut; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stat6 |
| Official Name | signal transducer and activator of transcription 6 [Source:MGI Symbol;Acc:MGI:103034] |
| Ensembl ID | ENSMUSG00000002147 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 6 |
| Synonyms | D12S1644, HIES6, IL-4 NAF, IL-4-STAT, signal transducer and activator of transcription 6, STAT6A, STAT6B, STAT6C, Stf-Il4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stat6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- LXXLL motif
- DNA binding domain
- STAT protein, DNA binding domain
- nucleic acid binding
- protein phosphatase binding
- transcription activation domain
- transcription factor binding
- linker domain
- coiled-coil domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- phosphorylation site
- STAT6 C-terminal
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the Stat6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- experimental autoimmune encephalomyelitis
- metastasis
- epithelial cancer
- cancer
- insulin resistance
- headache
- allergic sensitization
- autosomal dominant hyper-IgE recurrent infection syndrome 6
- acanthosis
role in cell
- expression in
- number
- quantity
- production in
- adhesion
- differentiation
- proliferation
- activation in
- upregulation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stat6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-4-mediated signaling pathway
- JAK-STAT cascade involved in growth hormone signaling pathway
- mammary gland morphogenesis
- signal transduction
- T-helper 1 cell lineage commitment
- defense response
- positive regulation of transcription from RNA polymerase II promoter
- response to peptide hormone stimulus
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of isotype switching to IgE isotypes
- cytokine-mediated signaling pathway
- isotype switching to IgE isotypes
- mammary gland epithelial cell proliferation
- regulation of mast cell proliferation
- cellular response to hydrogen peroxide
- negative regulation of type 2 immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein phosphatase binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity