H2-M9 Gene Summary [Mouse]

Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
H2-M9
Official Name
histocompatibility 2, M region locus 9 [Source:MGI Symbol;Acc:MGI:1276570]
Ensembl ID
ENSMUSG00000067201
Bio databases IDs NCBI: 14997 Ensembl: ENSMUSG00000067201
Aliases histocompatibility 2, M region locus 9
Synonyms H2-M1, H2-M9, H2-Qa-Mb1, histocompatibility 2, M region locus 1, histocompatibility 2, M region locus 9, M9, Mb1, RT1 class I, locus M1, gene 2, RT1-M1-2
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-M9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Immunoglobulin C1-set domain
  • Class I Histocompatibility antigen, domains alpha 1 and 2
  • MHC class I protein binding
  • natural killer cell lectin-like receptor binding
  • TAP binding
  • immunoglobulin domain
  • T-cell receptor binding
  • receptor binding
  • chaperone binding
  • peptide antigen binding
  • beta-2-microglobulin binding

Pathways

Biological processes and signaling networks where the H2-M9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • Golgi Apparatus
  • Endoplasmic Reticulum

Gene-Specific Assays for Results You Can Trust

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