Tcf3 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor binding activity; E-box binding activity; and protein heterodimerization activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on transcription by RNA polymerase II. Acts upstream of or within several processes, including immune system development; lymphocyte differentiation; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including brain; branchial arch; genitourinary system; integument; and retina. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 8A; agammaglobulinemia 8B; and colorectal cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf3 |
| Official Name | transcription factor 3 [Source:MGI Symbol;Acc:MGI:98510] |
| Ensembl ID | ENSMUSG00000020167 |
| Bio databases IDs | |
| Aliases | transcription factor 3 |
| Synonyms | A1, AGM8, AGM8A, AGM8B, ALF2, bHLHb21, E12/E47, E2-5, E2A, E47, ITF1, KA1, LOC100364490, LOC688265, ME2, p75, Pan1, Pan2, TCF3 isoform 1, Tcfe2a, TRANSCRIPTION FACTOR 3, VDIR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lsc-homology domain
- transcription regulator
- G1 cyclin dependent kinase site
- transcription activation domain
- transcription factor binding
- chromatin binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- basic domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- AD2 domain
- activation domain
- AD1 domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- MLK binding domain
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- Ubc binding domain
- protein binding
- activation domain AD1
- sequence-specific DNA binding
- nonacidic domain
- acidic domain
- DNA binding
- PDZ-domain binding
- loop-helix motif
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- protein homodimerization
- helix loop helix domain
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tcf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- B Cell Receptor Signaling
- Basal Cell Carcinoma Signaling
- DNA Methylation and Transcriptional Repression Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Ovarian Cancer Signaling
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- T-cell non-Hodgkin disease
- non-Hodgkin disease
- T cell cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- cancer
- hematological neoplasia
role in cell
- expression in
- degradation in
- activation in
- apoptosis
- replication in
- growth
- transmembrane potential
- formation
- cell death
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleosomes
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- B cell lineage commitment
- B cell differentiation
- positive regulation of transcription, DNA-dependent
- immunoglobulin V(D)J recombination
- nervous system development
- positive regulation of neuron differentiation
- regulation of transcription, DNA-dependent
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- euchromatin
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- bHLH transcription factor binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- vitamin D response element binding
- mitogen-activated protein kinase kinase kinase binding
- E-box binding