HHAT Gene Summary [Human]
'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | HHAT |
| Official Name | hedgehog acyltransferase [Source:HGNC Symbol;Acc:HGNC:18270] |
| Ensembl ID | ENSG00000054392 |
| Bio databases IDs | |
| Aliases | hedgehog acyltransferase, protein-cysteine N-palmitoyltransferase HHAT |
| Synonyms | 2810432O22Rik, AP-2CRE, FLJ10724, hedgehog acyltransferase, MART2, NNMS, RGD1311746, SKI1, Skn, Tg(TFAP2A-cre)1Will |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HHAT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- O-acyltransferase
Pathways
Biological processes and signaling networks where the HHAT gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HHAT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-terminal peptidyl-L-cysteine N-palmitoylation
- smoothened signaling pathway
- protein palmitoylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- O-acyltransferase activity
- palmitoyltransferase activity