USP37 Gene Summary [Human]
Enables cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP37 |
| Official Name | ubiquitin specific peptidase 37 [Source:HGNC Symbol;Acc:HGNC:20063] |
| Ensembl ID | ENSG00000135913 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 37 |
| Synonyms | 4932415L06RIK, C330008N13RIK, KIAA1594, ubiquitin specific peptidase 37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- protein kinase binding
- ubiquitin binding domain
- peptidase
- N-terminal of ubiquitin carboxyl-terminal hydrolase 37
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Pleckstrin homology-like domain
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP37 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- squamous cell cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung cancer
- squamous-cell carcinoma
- neoplastic cell transformation
- neonatal sepsis
role in cell
- proliferation
- expression in
- phosphorylation in
- binding in
- radiosensitivity
- stabilization in
- cisplatin sensitivity
- ubiquitination in
- polyubiquitination in
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein deubiquitination
- protein K11-linked deubiquitination
- G1/S transition of mitotic cell cycle
- proteolysis
- regulation of DNA replication
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein kinase binding
- protein binding
- cysteine-type endopeptidase activity