H2-M10.1 Gene Summary [Mouse]
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | H2-M10.1 |
| Official Name | histocompatibility 2, M region locus 10.1 [Source:MGI Symbol;Acc:MGI:1276522] |
| Ensembl ID | ENSMUSG00000024448 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, M region locus 10.1 |
| Synonyms | 15H, 4.7H, 5.3H, 6.9H, 9.5H, H2-M10.2, H2-M10.3, H2-M10.4, H2-M10.5, H2-M10.6, histocompatibility 2, M region locus 10.1, histocompatibility 2, M region locus 10.2, histocompatibility 2, M region locus 10.3, histocompatibility 2, M region locus 10.4, histocompatibility 2, M region locus 10.5, histocompatibility 2, M region locus 10.6, M10.7, M10.8 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-M10.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TAP2 binding
- Immunoglobulin C1-set domain
- MHC class I protein binding
- TAP binding
- TAP1 binding
- immunoglobulin domain
- T-cell receptor binding
- protein binding
- receptor binding
- identical protein binding
- beta-2-microglobulin binding
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- CD8 receptor binding
- protein homodimerization
- chaperone binding
- peptide antigen binding
Pathways
Biological processes and signaling networks where the H2-M10.1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- lysosome membrane
- endosomal membrane
- early endosomes
- perikaryon
- dendrites