Tapbp Gene Summary [Mouse]
Predicted to enable several functions, including MHC class I protein complex binding activity; TAP binding activity; and TAP complex binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and peptide antigen stabilization. Acts upstream of or within defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of Tapasin-ERp57 complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tapbp |
| Official Name | TAP binding protein [Source:MGI Symbol;Acc:MGI:1201689] |
| Ensembl ID | ENSMUSG00000024308 |
| Bio databases IDs | |
| Aliases | TAP binding protein |
| Synonyms | D17Wsu91e, MHC1D3, NGS17, TAPA, Tapasin, TAP binding protein, TPN, TPSN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tapbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TAP2 binding
- Immunoglobulin C1-set domain
- MHC class I protein binding
- binding protein
- TAP1 binding
- transmembrane/cytoplasmic domain
- immunoglobulin domain
- transmembrane domain
- protein binding
- cytosolic tail domain
- peptide antigen binding
- transporter
Pathways
Biological processes and signaling networks where the Tapbp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- early onset hypertension
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- insulin-dependent diabetes mellitus
- chronic interstitial cystitis
- bare lymphocyte syndrome, type I
role in cell
- binding in
- expression in
- function
- number
- development
- ubiquitination in
- antigen presentation by
- cytolysis by
- immune response
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tapbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide antigen assembly with MHC class I protein complex
- macromolecular complex assembly
- retrograde vesicle-mediated transport, Golgi to ER
- regulation of gene expression
- peptide antigen stabilization
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- protein folding
- MHC class Ib protein complex assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- MHC class I peptide loading complex
- phagocytic vesicle membrane
- Golgi membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- protein binding
- protein binding involved in protein folding
- peptide antigen binding
- unfolded protein binding
- MHC class I protein binding
- TAP1 binding
- TAP2 binding
- binding, bridging