Bax Gene Summary [Mouse]
Enables Hsp70 protein binding activity and identical protein binding activity. Involved in positive regulation of neuron apoptotic process. Acts upstream of or within several processes, including apoptotic signaling pathway; mitochondrion organization; and regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of BAX complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bax |
| Official Name | BCL2-associated X protein [Source:MGI Symbol;Acc:MGI:99702] |
| Ensembl ID | ENSMUSG00000003873 |
| Bio databases IDs | |
| Aliases | BCL2-associated X protein |
| Synonyms | Bcl2-associated X, BCL2 associated X, apoptosis regulator, BCL2-associated X protein, BCL2L4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bax often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- Bax transmembrane domain 1
- Hsp70 protein binding
- heat shock protein binding
- identical protein binding
- pocket domain
- Bcl-2 homology 1 domain
- Bcl-2 homology 3 domain
- chaperone binding
- basic domain
- loop domain
- apoptosis regulator
- mitochondrial presequence
- lipid binding
- Akt phosphorylation site
- channel/pore class transporter
- alpha helix
- protein domain specific binding
- protein binding
- BH3 binding domain
- binding protein
- Bcl-2 homology 2 domain
- transmembrane domain
- protein homodimerization
- IGDE motif
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Bax gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Aryl Hydrocarbon Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Huntington's Disease Signaling
- IL-7 Signaling Pathway
- IL-8 Signaling
- Induction of Apoptosis by HIV1
- Interferon Signaling
- Mitochondrial Dysfunction
- Myc Mediated Apoptosis Signaling
- NGF Signaling
- p53 Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Sirtuin Signaling Pathway
- Tumoricidal Function of Hepatic Natural Killer Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- hyperplasia
- cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- epithelial neoplasia
- bleeding
role in cell
- phosphorylation in
- expression in
- activation in
- proliferation
- binding in
- apoptosis
- survival
- cell death
- organization
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- endoplasmic reticulum fraction
- membrane fraction
- mitochondrial fraction
- mitochondrial envelope
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- granules
- cytosol
- endoplasmic reticulum membrane
- outer leaflet
- trans Golgi network
- mitochondrial membrane
- mitochondrial outer membrane
- nuclear envelope
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bax gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- spermatid differentiation
- response to axon injury
- induction of apoptosis via death domain receptors
- negative regulation of protein binding
- response to toxin
- calcium ion transport into cytosol
- glycosphingolipid metabolic process
- positive regulation of developmental pigmentation
- B cell homeostatic proliferation
- motor neuron apoptotic process
- kidney development
- regulation of mitochondrial membrane potential
- thymocyte apoptotic process
- apoptotic process
- negative regulation of peptidyl-serine phosphorylation
- cellular response to unfolded protein
- release of sequestered calcium ion into cytosol
- regulation of cell cycle
- response to gamma radiation
- positive regulation of intrinsic apoptotic signaling pathway
- protein insertion into mitochondrial membrane
- positive regulation of motor neuron apoptotic process
- germ cell programmed cell death
- retinal cell programmed cell death
- fertilization
- regulation of apoptotic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- development of secondary sexual characteristics
- positive regulation of endoplasmic reticulum unfolded protein response
- cerebral cortex development
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
- signal transduction by p53 class mediator resulting in induction of apoptosis
- release of cytochrome c from mitochondria
- positive regulation of reproductive process
- regulation of nitrogen utilization
- vagina development
- response to salt stress
- reduction of endoplasmic reticulum calcium ion concentration
- extrinsic apoptotic signaling pathway
- apoptotic signaling pathway
- odontogenesis of dentin-containing tooth
- myeloid cell homeostasis
- intrinsic apoptotic signaling pathway
- hypothalamus development
- extrinsic apoptotic signaling pathway in absence of ligand
- execution phase of apoptosis
- positive regulation of neuron apoptotic process
- negative regulation of neuron apoptotic process
- neuron migration
- apoptotic mitochondrial changes
- negative regulation of mitochondrial membrane potential
- negative regulation of fibroblast proliferation
- cellular response to UV
- regulation of mammary gland epithelial cell proliferation
- endoplasmic reticulum calcium ion homeostasis
- positive regulation of protein complex assembly
- Sertoli cell proliferation
- germ cell development
- apoptotic process involved in mammary gland involution
- positive regulation of apoptotic process involved in mammary gland involution
- positive regulation of release of cytochrome c from mitochondria
- mitochondrial fusion
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of release of sequestered calcium ion into cytosol
- B cell negative selection
- B cell homeostasis
- B cell apoptotic process
- ovarian follicle development
- blood vessel remodeling
- T cell homeostatic proliferation
- homeostasis of number of cells within a tissue
- post-embryonic camera-type eye morphogenesis
- positive regulation of apoptotic process
- establishment or maintenance of transmembrane electrochemical gradient
- positive regulation of B cell apoptotic process
- positive regulation of calcium ion transport into cytosol
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- release of matrix enzymes from mitochondria
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- pore complex
- endoplasmic reticulum
- mitochondrial outer membrane
- BAX complex
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- BAK complex
- mitochondrial permeability transition pore complex
- extracellular vesicular exosome
- cytoplasm
- Bcl-2 family protein complex
- membrane
- mitochondrion
- cytosol
- cell periphery
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- BH3 domain binding
- identical protein binding
- channel activity
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- lipid binding
- Hsp70 protein binding