Ctsw Gene Summary [Mouse]

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of the encoded protein is upregulated following lymphocyte activation. Data from a human cell line suggests that the encoded enzyme may be important for viral entry into host cells. [provided by RefSeq, Aug 2015]

Details

Type
Retained Intron
Official Symbol
Ctsw
Official Name
cathepsin W [Source:MGI Symbol;Acc:MGI:1338045]
Ensembl ID
ENSMUSG00000024910
Bio databases IDs NCBI: 13041 Ensembl: ENSMUSG00000024910
Aliases cathepsin W
Synonyms Cathepsin w, lymphopain, LYPN
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsw often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cysteine-type peptidase
  • Cathepsin propeptide inhibitor domain (I29)
  • peptidase
  • Peptidase_C1

Pathways

Biological processes and signaling networks where the Ctsw gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • systemic lupus erythematosus
  • osteoporosis
  • insulin-dependent diabetes mellitus
  • essential thrombocythemia
  • pemphigus foliaceus
regulated by
role in cell
  • replication in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • secretory granule lumen
  • Extracellular Space
  • lysosome
  • Endoplasmic Reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsw gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • immune response
  • proteolysis involved in cellular protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • membrane
  • endoplasmic reticulum
  • platelet dense granule lumen
  • extracellular region
  • lysosome

Molecular Function

What the gene product does at the molecular level
  • cysteine-type endopeptidase activity
  • cysteine-type peptidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.