Il2 Gene Summary [Mouse]
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il2 |
| Official Name | interleukin 2 [Source:MGI Symbol;Acc:MGI:96548] |
| Ensembl ID | ENSMUSG00000027720 |
| Bio databases IDs | |
| Aliases | interleukin 2 |
| Synonyms | interleukin 2, lymphokine, TCGF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- termination codon
- sphingolipid binding
- lipid binding
- ER targeting sequence
- G-protein-coupled receptor binding
- protein binding
- cytokine
- growth factor
- Interleukin 2
- interleukin-2 receptor binding
- binding protein
- kinase activator
- carbohydrate binding
Pathways
Biological processes and signaling networks where the Il2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- CD28 Signaling in T Helper Cells
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Erythropoietin Signaling
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-17 Signaling
- IL-2 Signaling
- Natural Killer Cell Signaling
- OX40 Signaling Pathway
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- metastasis
- infection
- chronic lymphocytic leukemia
- diabetes mellitus
- plasma cell myeloma
- COVID-19
- acute myeloid leukemia
- myelodysplastic syndrome
phenotypes
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal CD8 positive alpha-beta intraepithelial T cell morphology
- abnormal T cell activation
- abnormal T cell proliferation
- abnormal T-helper 1 cell differentiation
- abnormal bone marrow cell number
- abnormal cellular respiration
- abnormal circulating cytokine level
- abnormal class switch recombination
- abnormal colon goblet cell morphology
- abnormal cytotoxic T cell physiology
- abnormal gamma-delta intraepithelial T cell morphology
- abnormal intestinal epithelium morphology
- abnormal level of surface class II molecules
- abnormal lymphocyte cell number
- abnormal lymphocyte morphology
- abnormal lymphocyte physiology
- abnormal regulatory T cell physiology
- abnormal response to transplant
- abnormal reticulocyte morphology
- abnormal salivary gland duct morphology
- abnormal salivary gland morphology
- abnormal spleen morphology
- abnormal thymocyte activation
- altered susceptibility to Riboviria infection
- altered susceptibility to autoimmune disorder
- amyloidosis
- anemia
- cachexia
- chronic diarrhea
- colitis
- crypts of Lieberkuhn abscesses
- decreased CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased T cell proliferation
- decreased circulating interferon-gamma level
- decreased circulating interleukin-13 level
- decreased circulating interleukin-4 level
- decreased cytotoxic T cell cytolysis
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased hematocrit
- decreased regulatory T cell number
- decreased salivation
- decreased splenocyte proliferation
- diarrhea
- enlarged lymph nodes
- enlarged mesenteric lymph nodes
- enlarged spleen
- heart inflammation
- hunched posture
- impaired natural killer cell mediated cytotoxicity
- increased B cell proliferation
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgA level
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased T cell number
- increased T cell proliferation
- increased T-helper 17 cell number
- increased activated T cell number
- increased circulating bilirubin level
- increased circulating interleukin-17 level
- increased double-negative T cell number
- increased germinal center B cell number
- increased inflammatory response
- increased length of allograft survival
- increased mean corpuscular hemoglobin
- increased plasma cell number
- increased pre-B cell number
- increased pro-B cell number
- increased regulatory T cell number
- increased single-positive T cell number
- increased spleen red pulp amount
- increased splenocyte number
- increased susceptibility to autoimmune diabetes
- increased susceptibility to autoimmune disorder
- increased susceptibility to autoimmune hemolytic anemia
- intestinal ulcer
- lacrimal gland inflammation
- large intestinal inflammation
- liver inflammation
- low mean erythrocyte cell number
- lung inflammation
- lymph node hyperplasia
- pancreas inflammation
- premature death
- rectal hemorrhage
- rectal prolapse
- salivary gland inflammation
- spleen hyperplasia
- vasculitis
role in cell
- phosphorylation in
- expression in
- recruitment
- killing
- cell death
- production in
- migration
- loss
- activation in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- vesicles
- lysosome
- Golgi Apparatus
- recycling endosomes
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-2-mediated signaling pathway
- positive regulation of cell proliferation
- transcription from RNA polymerase II promoter
- cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- leukocyte activation involved in immune response
- positive regulation of regulatory T cell differentiation
- response to ethanol
- positive regulation of cell growth
- negative regulation of lymphocyte proliferation
- immune response
- positive regulation of interferon-gamma production
- positive regulation of tissue remodeling
- positive regulation of immunoglobulin production
- positive regulation of interleukin-17 production
- natural killer cell activation
- activated T cell proliferation
- negative regulation of inflammatory response
- positive regulation of plasma cell differentiation
- positive regulation of inflammatory response
- cell-cell signaling
- adaptive immune response
- positive regulation of dendritic spine development
- positive regulation of isotype switching to IgG isotypes
- protein kinase C-activating G-protein coupled receptor signaling pathway
- positive regulation of activated T cell proliferation
- elevation of cytosolic calcium ion concentration
- T cell differentiation
- regulation of T cell homeostatic proliferation
- negative regulation of apoptotic process
- negative regulation of protein phosphorylation
- negative regulation of B cell apoptotic process
- positive regulation of B cell proliferation
- negative regulation of T-helper 17 cell differentiation
- regulation of CD4-positive, alpha-beta T cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosphingolipid binding
- kinase activator activity
- growth factor activity
- protein binding
- interleukin-2 receptor binding
- cytokine activity
- carbohydrate binding
- kappa-type opioid receptor binding