Il2 Gene Summary [Mouse]
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il2 |
| Official Name | interleukin 2 [Source:MGI Symbol;Acc:MGI:96548] |
| Ensembl ID | ENSMUSG00000027720 |
| Bio databases IDs | |
| Aliases | interleukin 2 |
| Synonyms | interleukin 2, lymphokine, TCGF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- termination codon
- sphingolipid binding
- lipid binding
- ER targeting sequence
- G-protein-coupled receptor binding
- protein binding
- cytokine
- growth factor
- Interleukin 2
- interleukin-2 receptor binding
- binding protein
- kinase activator
- carbohydrate binding
Pathways
Biological processes and signaling networks where the Il2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Erythropoietin Signaling
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- IL-17 Signaling
- IL-2 Signaling
- Natural Killer Cell Signaling
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Telomerase Signaling
- Th1 Pathway
- Th2 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- metastasis
- infection
- chronic lymphocytic leukemia
- diabetes mellitus
- plasma cell myeloma
- COVID-19
- acute myeloid leukemia
- myelodysplastic syndrome
role in cell
- phosphorylation in
- expression in
- recruitment
- killing
- cell death
- production in
- migration
- loss
- activation in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- vesicles
- lysosome
- Golgi Apparatus
- recycling endosomes
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-2-mediated signaling pathway
- positive regulation of cell proliferation
- transcription from RNA polymerase II promoter
- cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- leukocyte activation involved in immune response
- positive regulation of regulatory T cell differentiation
- response to ethanol
- positive regulation of cell growth
- negative regulation of lymphocyte proliferation
- immune response
- positive regulation of interferon-gamma production
- positive regulation of tissue remodeling
- positive regulation of immunoglobulin production
- positive regulation of interleukin-17 production
- natural killer cell activation
- activated T cell proliferation
- negative regulation of inflammatory response
- positive regulation of plasma cell differentiation
- positive regulation of inflammatory response
- cell-cell signaling
- adaptive immune response
- positive regulation of dendritic spine development
- positive regulation of isotype switching to IgG isotypes
- protein kinase C-activating G-protein coupled receptor signaling pathway
- positive regulation of activated T cell proliferation
- elevation of cytosolic calcium ion concentration
- T cell differentiation
- regulation of T cell homeostatic proliferation
- negative regulation of apoptotic process
- negative regulation of protein phosphorylation
- negative regulation of B cell apoptotic process
- positive regulation of B cell proliferation
- negative regulation of T-helper 17 cell differentiation
- regulation of CD4-positive, alpha-beta T cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosphingolipid binding
- kinase activator activity
- growth factor activity
- protein binding
- interleukin-2 receptor binding
- cytokine activity
- carbohydrate binding
- kappa-type opioid receptor binding