Kir3dl1

Predicted to enable several functions, including MHC class Ib protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1) and KIR3DL3 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kir3dl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Kir3dl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.