Kir3dl1 Gene Summary [Rat]
Predicted to enable molecular adaptor activity. Predicted to be involved in immune response-regulating signaling pathway and natural killer cell mediated cytotoxicity. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kir3dl1 |
| Official Name | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [Source:RGD Symbol;Acc:727836] |
| Ensembl ID | ENSRNOG00000027843 |
| Bio databases IDs | |
| Aliases | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 |
| Synonyms | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1, Kir3dl1, Kir3dl2, Kirl1, Kirl2, Krl1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kir3dl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- MHC protein binding
- immunoglobulin domain
- Immunoglobulin like
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Kir3dl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomal membrane