Ecm2 Gene Summary [Mouse]
Enables collagen V binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in interstitial matrix. Is expressed in several structures, including brain; heart valve; sensory organ; tendon; and ventricular layer. Orthologous to human ECM2 (extracellular matrix protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ecm2 |
| Official Name | extracellular matrix protein 2, female organ and adipocyte specific [Source:MGI Symbol;Acc:MGI:3039578] |
| Ensembl ID | ENSMUSG00000043631 |
| Bio databases IDs | |
| Aliases | extracellular matrix protein 2, female organ and adipocyte specific |
| Synonyms | 9030618O22RIK, extracellular matrix protein 2, extracellular matrix protein 2, female organ and adipocyte specific, LOC100361383, LOC100910978, tenonectin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ecm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- von Willebrand factor type C domain
- protein phosphatase 1 regulatory subunit 42
- integrin binding
- Leucine rich repeat
- collagen binding
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- heparin binding
Pathways
Biological processes and signaling networks where the Ecm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ecm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- extracellular matrix organization
- positive regulation of cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- interstitial matrix
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- collagen V binding
- heparin binding
- integrin binding