Smarca4 Gene Summary [Mouse]
Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and lncRNA binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of metabolic process. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including blastocyst development; circulatory system development; and erythrocyte differentiation. Located in euchromatin; male germ cell nucleus; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid tumor predisposition syndrome 2. Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarca4 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [Source:MGI Symbol;Acc:MGI:88192] |
| Ensembl ID | ENSMUSG00000032187 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Synonyms | b2b508.1Clo, b2b692Clo, BAF190, BAF190A, BRG, BRG1, CSS4, HP1-BP72, hSNF2b, MRD16, OTSC12, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SNF2-β, SW1/SNF, SWI2, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smarca4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Snf2-ATP coupling, chromatin remodelling complex
- transcription regulator
- transcription co-activator
- ATP-binding domain
- helicase
- transcription co-repressor
- androgen receptor binding
- transcription factor binding
- chromatin binding
- LXCXE binding site
- Bromodomain
- ATPase
- Helicase conserved C-terminal domain
- proline rich domain
- retinoblastoma protein binding domain
- QLQ
- helicase domain
- arginine-lysine rich domain
- ATPase domain
- BRK domain
- helicase/SANT associated domain
- BRM and KIS domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- histone binding
- domain in helicases and associated with SANT domains
- nucleic acid binding
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- SNF2-related domain
- enzyme binding
- protein binding
- p53 binding
- DNA dependent ATPase
- HSA domain
- sequence-specific DNA binding
- RNA binding
- binding protein
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Smarca4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cholangiocarcinoma cancer
- epithelial cancer
- pancreaticobiliary cancer
- cancer
- digestive system cancer
- abdominal cancer
- liver cancer
- COVID-19
role in cell
- binding in
- phosphorylation in
- activation in
- cellular infiltration by
- migration
- formation
- formation in
- invasion by
- expression in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear matrix fraction
- perichromatin fibril
- fibrillar center
- nuclear chromatin
- Cytoplasm
- intranuclear region
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smarca4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- regulation of mitotic metaphase/anaphase transition
- positive regulation of cell proliferation
- nervous system development
- positive regulation of myoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of nucleotide-excision repair
- negative regulation of androgen receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- negative regulation of cell differentiation
- neural retina development
- positive regulation of gene expression, epigenetic
- positive regulation of cell differentiation
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- RNA polymerase I transcriptional preinitiation complex assembly
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of Wnt receptor signaling pathway
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- kinetochore
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
- nucleus
- extracellular space
- npBAF complex
- membrane
- nuclear matrix
- macromolecular complex
- nBAF complex
- RSC complex
Molecular Function
What the gene product does at the molecular level
- DNA-dependent ATPase activity
- nucleosomal DNA binding
- helicase activity
- transcription factor binding
- transcription cofactor binding
- ATP binding
- DNA binding
- DNA polymerase binding
- p53 binding
- RNA binding
- RNA polymerase I CORE element sequence-specific DNA binding
- protein binding
- androgen receptor binding
- transcription coactivator activity
- Tat protein binding
- transcription corepressor activity
- histone acetyl-lysine binding
- hydrolase activity