Met Gene Summary [Mouse]
Enables hepatocyte growth factor receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including hepatocyte growth factor receptor signaling pathway; regulation of cytokine production; and striated muscle cell differentiation. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Met |
| Official Name | met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] |
| Ensembl ID | ENSMUSG00000009376 |
| Bio databases IDs | |
| Aliases | met proto-oncogene |
| Synonyms | AI838057, AUTS9, c-Met, DA11, DFNB97, HGF, HGF Binding, HGFR, LOC360378, met proto-oncogene, MET proto-oncogene, receptor tyrosine kinase, MetR, PAR4, RCCP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Met often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- membrane-association domain
- protein-tyrosine kinase
- identical protein binding
- Grb2 binding domain
- semaphorin domain
- Hepatocyte growth factor binding domain
- cytoplasmic domain
- cysteine rich domain
- transmembrane receptor
- glycine rich domain
- extracellular domain
- intracellular loop
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- IPT
- beta-catenin binding
- protein phosphatase binding
- ectodomain
- hepatocyte growth factor receptor
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- dileucine internalization motif
- transmembrane domain
- IPT/TIG domain
- tyrosine kinase domain
- substrate binding domain
- PI3K binding domain
- Src binding domain
- protein kinase
- Plexin repeat
- regulatory domain
- ATP-binding domain
- Protein kinase domain
- docking domain
- intracellular domain
- membrane-proximal domain
- Sema domain
- Tyrosine kinase, catalytic domain
- cytoplasmic kinase domain
- DpYR motif
- Protein kinase (unclassified specificity)
- enzyme binding
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- binding protein
- transmembrane/cytoplasmic domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Met gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Clathrin-mediated Endocytosis Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- FGF Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HGF Signaling
- HIF1α Signaling
- IL-15 Production
- IL-7 Signaling Pathway
- Macropinocytosis Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Remodeling of Epithelial Adherens Junctions
- Renal Cell Carcinoma Signaling
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
- Sperm Motility
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver metastasis
- pancreatic endocrine tumor
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- osteosarcomagenesis
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- binding in
- invasion by
- dephosphorylation in
- upregulation in
- production in
- signaling in
- expression in
- apoptosis
- cell viability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- membrane fraction
- membrane nanotubes
- inner surface
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cell-cell contacts
- apical cell surfaces
- apical membrane
- postsynaptic membrane
- basolateral membrane
- basal membrane
- sperm tail
- growth cone
- neurites
- endocytotic vesicle
- anchoring junction
- perikaryon
- dendrites
- excitatory synapses
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Met gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- multicellular organismal development
- positive chemotaxis
- nervous system development
- branching morphogenesis of a tube
- positive regulation of transcription from RNA polymerase II promoter
- establishment of skin barrier
- endothelial cell morphogenesis
- liver development
- positive regulation of endothelial cell chemotaxis
- positive regulation of kinase activity
- positive regulation of microtubule polymerization
- cell migration
- pancreas development
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- neuron differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell surface receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- negative regulation of stress fiber assembly
- negative regulation of autophagy
- negative regulation of thrombin receptor signaling pathway
- phagocytosis
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- receptor complex
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- hepatocyte growth factor-activated receptor activity
- ATP binding
- identical protein binding
- protein tyrosine kinase activity
- protein phosphatase binding
- protein binding
- semaphorin receptor activity