RENBP Gene Summary [Human]
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RENBP |
| Official Name | renin binding protein [Source:HGNC Symbol;Acc:HGNC:9959] |
| Ensembl ID | ENSG00000102032 |
| Bio databases IDs | |
| Aliases | renin binding protein, N-acylglucosamine 2-epimerase, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase |
| Synonyms | Age, RBP, renin binding protein, RNBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RENBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- protease inhibitor
- enzyme inhibitor activity
- ATP binding
- AGE
- enzyme
- protein binding
- purine nucleotide binding
- identical protein binding
- N-acylglucosamine 2-epimerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RENBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- N-acetylneuraminate catabolic process
- N-acetylmannosamine metabolic process
- N-acetylglucosamine metabolic process
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- identical protein binding
- endopeptidase inhibitor activity
- protein binding
- N-acylglucosamine 2-epimerase activity