ZBED1 Gene Summary [Human]
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZBED1 |
| Official Name | zinc finger BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447] |
| Ensembl ID | ENSG00000214717 |
| Bio databases IDs | |
| Aliases | zinc finger BED-type containing 1 |
| Synonyms | ALTE, DREF, dREF homolog, hDREF, TRAMP, ZBED1X, zinc finger BED-type containing 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBED1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO ligase
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription co-activator
- SUMO transferase activity
- nucleic acid binding
- nuclear localization sequence
- transcription cofactor
- hAT family C-terminal dimerization region
- enzyme
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Domain of unknown function (DUF4413)
- BED zinc finger
- hATC domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
- nuclear envelope
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBED1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- centrosome
- PML body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- SUMO ligase activity