MS4A6A Gene Summary [Human]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]

Details

Type
Protein Coding
Official Symbol
MS4A6A
Official Name
membrane spanning 4-domains A6A [Source:HGNC Symbol;Acc:HGNC:13375]
Ensembl ID
ENSG00000110077
Bio databases IDs NCBI: 64231 Ensembl: ENSG00000110077
Aliases membrane spanning 4-domains A6A
Synonyms 4SPAN3, 4SPAN3.2, CD20L3, CDA01, membrane spanning 4-domains A6A, MS4A6, MST090, MSTP090
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MS4A6A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • CD20-like family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • epithelial cancer
  • liver cancer
  • renal clear cell adenocarcinoma
  • diabetic nephropathy
  • venous thromboembolism
  • hepatocellular carcinoma
  • Alzheimer disease
  • coronary artery disease
  • ischemic stroke
  • endometriosis
regulated by
  • deferasirox
  • GRN
  • Immunoglobulin
  • deferoxamine
  • cholecalciferol
  • TFRC
  • 3alpha-aminocholestane
  • filgrastim
  • dexamethasone

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • trans Golgi network

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MS4A6A gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell surface receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • trans-Golgi network
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.