TFRC Gene Summary [Human]
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | TFRC |
| Official Name | transferrin receptor [Source:HGNC Symbol;Acc:HGNC:11763] |
| Ensembl ID | ENSG00000072274 |
| Bio databases IDs | |
| Aliases | transferrin receptor |
| Synonyms | 2610028K12Rik, CD71, E430033M20Rik, IMD46, LOC105374300, Mtvr-1, p90, T9, TFNR, TFR, TFR1, TR, Transferrin Receptor, TRANSFERRIN receptor 1, Trfc, TRFR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFRC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- transferrin receptor
- identical protein binding
- PA domain
- Zinc peptidases M18, M20, M28, and M42
- cytoplasmic domain
- PA
- Transferrin receptor-like dimerization domain
- double-stranded RNA binding
- chaperone binding
- extracellular domain
- protein kinase binding
- ectodomain
- helical domain
- RGD motif
- iron ion transporter
- protein binding
- Peptidase family M28
- sorting signal domain
- binding protein
- transmembrane domain
- protein homodimerization
- protease like domain
- cytosolic tail domain
- protease-like domain
- apical domain
- transporter
Pathways
Biological processes and signaling networks where the TFRC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- infection
- sepsis
- anemia
- diabetes mellitus
- cancer
- rheumatoid arthritis
- celiac disease
- organismal death
- epithelial cancer
role in cell
- growth
- expression in
- phosphorylation in
- migration
- number
- loss
- apoptosis
- quantity
- survival
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- high-density microsomal fractions
- soluble fraction
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- endosomal membrane fractions
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cortical endoplasmic reticulum
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- Golgi region
- cell borders
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- postsynaptic region
- pericentriolar regions
- membrane surface
- cellular membrane
- Nucleus
- vacuole
- endosomes
- vesicles
- Golgi Apparatus
- granules
- cytoplasmic aggregates
- cytosol
- basolateral cell surfaces
- plasma membrane extracellular face
- apical membrane
- endocytic zone
- basolateral membrane
- endosomal membrane
- perinuclear space
- nodes of Ranvier
- Schmidt-Lanterman incisures
- recycling endosomes
- early endosomes
- peri-Golgi vesicles
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- GLUT4 vesicles
- multivesicular bodies
- Golgi cisternae
- brush border
- clathrin-coated pits
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- Golgi vesicles
- exosomes
- plasma
- perinuclear recycling endosome
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFRC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to manganese ion
- viral entry into host cell
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- cellular iron ion homeostasis
- response to retinoic acid
- response to hypoxia
- negative regulation of mitochondrial fusion
- response to iron ion
- intracellular signal transduction
- positive regulation of protein complex assembly
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of protein localization to nucleus
- transferrin transport
- response to copper ion
- positive regulation of isotype switching
- response to nutrient
- positive regulation of T cell proliferation
- acute-phase response
- regulation of cell proliferation
- osteoclast differentiation
- regulation of cell growth
- positive regulation of bone resorption
- positive regulation of gene expression
- negative regulation of apoptotic process
- iron ion transport
- positive regulation of protein phosphorylation
- positive regulation of B cell proliferation
- cellular response to xenobiotic stimulus
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
- cell surface
- extracellular space
- early endosome
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- melanosome
- coated pit
- intracellular membrane-bounded organelle
- blood microparticle
- membrane
- cytoplasmic vesicle
- recycling endosome
- endosome membrane
- recycling endosome membrane
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein homodimerization activity
- RNA binding
- transferrin receptor activity
- protein binding
- double-stranded RNA binding
- viral receptor activity
- Hsp70 protein binding