GLYAT Gene Summary [Human]
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GLYAT |
| Official Name | glycine-N-acyltransferase [Source:HGNC Symbol;Acc:HGNC:13734] |
| Ensembl ID | ENSG00000149124 |
| Bio databases IDs | |
| Aliases | glycine-N-acyltransferase |
| Synonyms | ACGNAT, CAT, GAT, glycine-N-acyltransferase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLYAT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine N-benzoyltransferase
- glycine N-acyltransferase
- Aralkyl acyl-CoA:amino acid N-acyltransferase
- NAT_SF
- enzyme
- protein binding
- transferase, transferring acyl groups
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- open-angle glaucoma
- cardiovascular disorder
- Crohn disease
- ulcerative colitis
- inflammatory bowel disease
- renal clear cell adenocarcinoma
regulates
- acyl-coenzyme A
- xenobiotic
- L-ornithine
- glycine
- creatine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLYAT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- xenobiotic metabolic process
- response to toxin
- glycine metabolic process
- monocarboxylic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- protein binding
- glycine N-acyltransferase activity
- glycine N-benzoyltransferase activity