FCRLB Gene Summary [Human]
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | FCRLB |
| Official Name | Fc receptor like B [Source:HGNC Symbol;Acc:HGNC:26431] |
| Ensembl ID | ENSG00000162746 |
| Bio databases IDs | |
| Aliases | Fc receptor like B |
| Synonyms | Fc receptor-like B, FCRL2, FCRLM2, FCRLY, FcRY, FREB-2, mFCRL2, RGD1563018 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCRLB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCRLB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cell surface receptor signaling pathway
- negative regulation of immune response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity