CLEC6A Gene Summary [Human]
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | CLEC6A |
| Official Name | C-type lectin domain containing 6A [Source:HGNC Symbol;Acc:HGNC:14556] |
| Ensembl ID | ENSG00000205846 |
| Bio databases IDs | |
| Aliases | C-type lectin domain containing 6A |
| Synonyms | CLEC4N, Clec6a-ps1, CLECSF10, C-type lectin domain containing 6A, C-type lectin domain family 6, member A, pseudogene 1, dectin-2, Dectin-2p, hDECTIN-2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC6A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- calcium ion binding
- enzyme binding
- protein binding
- carbohydrate binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- alpha-mannan
- CLEC4D
disease
- breast cancer
regulated by
- Candida albicans strain SC5314
- monocyte-derived macrophages
- alpha-mannan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC6A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T-helper 17 type immune response
- response to yeast
- innate immune response
- detection of yeast
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- adaptive immune response
- defense response to fungus
- positive regulation of cytokine production
- positive regulation of peptidyl-tyrosine phosphorylation
- stimulatory C-type lectin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- calcium ion binding
- phospholipase binding
- carbohydrate binding