SERPINE3 Gene Summary [Human]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERPINE3 |
| Official Name | serpin family E member 3 [Source:HGNC Symbol;Acc:HGNC:24774] |
| Ensembl ID | ENSG00000253309 |
| Bio databases IDs | |
| Aliases | serpin family E member 3 |
| Synonyms | E130113E03Rik, LOC683254, RGD1310515, serpin family E member 3, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINE3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
- glioblastoma
- glioblastoma cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
regulated by
- SPDEF
- 4,5,6,7-tetrabromo-2-azabenzamidazole
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINE3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity