Alox12e Gene Summary [Mouse]
Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonate metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox12e |
| Official Name | arachidonate lipoxygenase, epidermal [Source:MGI Symbol;Acc:MGI:1274790] |
| Ensembl ID | ENSMUSG00000018907 |
| Bio databases IDs | |
| Aliases | arachidonate lipoxygenase, epidermal |
| Synonyms | 12-LOX, 12-LOX-e, 8-LOX, Alox12-ps1, Alox12-ps2, Aloxe, arachidonate 12-lipoxygenase, epidermal, arachidonate lipoxygenase, epidermal, E-12/15-Lox, E(12s)-lox, E12S-LOX, e-LOX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alox12e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- arachidonate 12-lipoxygenase
- PLAT
- enzyme
- Lipoxygenase homology 2 (beta barrel) domain
Pathways
Biological processes and signaling networks where the Alox12e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- reactive oxygen species
- methyl linoleate
- arachidonic acid
- 5,8,11-eicosatrienoic acid
- arachidonic acid methyl ester
- 8,11,14-eicosatrienoic acid
- 12(S)-hydroxyeicosatetraenoic acid
- docosahexaenoic acid
- 14-hydroxy-4,7,10,12,16,19-docosahexaenoic acid
- 13(S)-hydroxyoctadecadienoic acid
disease
- tumorigenesis
phenotypes
- decreased blood urea nitrogen level
- decreased circulating insulin level
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm