Akr1cl

Predicted to enable several functions, including geranylgeranyl reductase activity; oxidoreductase activity, acting on CH-OH group of donors; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in adrenal medulla; interstitium of the testis; seminiferous cord; testis; and urogenital ridge. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1cl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Akr1cl gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.