Kcnk10 Gene Summary [Mouse]
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk10 |
| Official Name | potassium channel, subfamily K, member 10 [Source:MGI Symbol;Acc:MGI:1919508] |
| Ensembl ID | ENSMUSG00000033854 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 10 |
| Synonyms | 1700024D23RIK, 3010005K24Rik, K2p10.1, LOC100128205, potassium channel, subfamily K, member 10, potassium two pore domain channel subfamily K member 10, PPP1R97, TREK-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- channel/pore class transporter
- Pka phosphorylation site
- mechanically-gated ion channel
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- preeclampsia
- overall survival
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulated by
- lysophosphatidylcholine
- fatty acid
- arachidonic acid
- isoflurane
- linoleic acid
- docosahexaenoic acid
- oleic acid
- phosphatidic acid
- HTR4
- baicalein
role in cell
- excitation
- response by
- excitability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- signal transduction
- memory
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- outward rectifier potassium channel activity
- potassium channel activity
- potassium ion leak channel activity