Htr4 Gene Summary [Mouse]
Enables G protein-coupled serotonin receptor activity. Involved in several processes, including maintenance of gastrointestinal epithelium; mucus secretion; and regulation of postsynapse assembly. Is active in glutamatergic synapse; plasma membrane; and postsynapse. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr4 |
| Official Name | 5 hydroxytryptamine (serotonin) receptor 4 [Source:MGI Symbol;Acc:MGI:109246] |
| Ensembl ID | ENSMUSG00000026322 |
| Bio databases IDs | |
| Aliases | 5 hydroxytryptamine (serotonin) receptor 4 |
| Synonyms | 5-HT, 5-HT-4, 5-HT4R, 5HTR4, 5-hydroxytryptamine receptor 4, 5 hydroxytryptamine (serotonin) receptor 4, Serotonin receptor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Taste receptor protein (TAS2R)
- Cholecystokinin A receptor, N-terminal
- serotonin receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- migraines
- anorexia
- obesity
- migraine variant
- diabetic gastroparesis
- diabetes mellitus
- visceral hypersensitive reaction
- chronic obstructive pulmonary disease
- dyspepsia
regulated by
- BIMU 8
- tegaserod
- beta-estradiol
- 5-methoxytryptamine
- ZFPM1
- 5-hydroxytryptamine
- renzapride
- GRK
- SL-650155
- RS 67333
role in cell
- activity
- expression in
- production in
- quantity
- replication in
- formation in
- number
- expansion
- maintenance
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- somatodendritic region
- postsynaptic region
- cellular membrane
- dense granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of appetite
- mucus secretion
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- maintenance of gastrointestinal epithelium
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- endosome
- cytoplasm
- membrane
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity