Npy6r Gene Summary [Mouse]
Enables peptide YY receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be active in neuron projection and plasma membrane. Is expressed in embryo. Orthologous to human NPY6R (neuropeptide Y receptor Y6 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npy6r |
| Official Name | neuropeptide Y receptor Y6 [Source:MGI Symbol;Acc:MGI:1098590] |
| Ensembl ID | ENSMUSG00000038071 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y6 |
| Synonyms | neuropeptide Y receptor Y6 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npy6r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- peptide YY receptor
- Cholecystokinin A receptor, N-terminal
- neuropeptide Y receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- ESR1
- estradiol-17beta-benzoate
phenotypes
- abnormal abdominal fat pad morphology
- abnormal circulating corticosterone level
- abnormal circulating insulin-like growth factor I level
- abnormal energy expenditure
- abnormal food intake
- abnormal motor coordination/ balance
- decreased body size
- decreased body weight
- decreased brown adipose tissue amount
- decreased circulating insulin level
- decreased circulating insulin-like growth factor I level
- decreased defecation amount
- decreased epididymal fat pad weight
- decreased food intake
- decreased inguinal fat pad weight
- decreased lean body mass
- decreased mesenteric fat pad weight
- decreased respiratory quotient
- decreased retroperitoneal fat pad weight
- decreased total body fat amount
- hepatic steatosis
- hyperactivity
- impaired glucose tolerance
- improved glucose tolerance
- increased brown adipose tissue amount
- increased circulating glucose level
- increased circulating insulin level
- increased defecation amount
- increased energy expenditure
- increased epididymal fat pad weight
- increased food intake
- increased inguinal fat pad weight
- increased liver weight
- increased respiratory quotient
- increased retroperitoneal fat pad weight
- increased susceptibility to age related obesity
- increased susceptibility to diet-induced obesity
- increased total body fat amount
- increased white adipose tissue amount
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane