Ddo Gene Summary [Mouse]
Enables D-aspartate oxidase activity and FAD binding activity. Involved in D-amino acid catabolic process; nervous system process; and regulation of cell communication. Acts upstream of or within several processes, including aspartate metabolic process; grooming behavior; and insemination. Predicted to be located in cytosol and peroxisomal matrix. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; chordamesoderm; nervous system; respiratory system; and sensory organ. Orthologous to human DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddo |
| Official Name | D-aspartate oxidase [Source:MGI Symbol;Acc:MGI:1925528] |
| Ensembl ID | ENSMUSG00000063428 |
| Bio databases IDs | |
| Aliases | D-aspartate oxidase |
| Synonyms | 5330420D20Rik, 5730402C02RIK, AI467244, DASOX, D-ASPARATE OXIDASE, D-aspartate oxidase, DASPO, DDO-1, DDO-2, LOC100911156, LOC682944 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- FAD dependent oxidoreductase
- enzyme
- protein binding
- D-aspartate oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DAOA
- PEX5
disease
- major depression
- systemic lupus erythematosus
- weight gain
- productive infection by HIV-1
regulates
- D-amino acid
- hormone
- L-aspartic acid
- D-aspartic acid
role in cell
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- grooming behavior
- D-amino acid catabolic process
- regulation of cell communication
- insemination
- hormone metabolic process
- neurological system process
- aspartate catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytoplasm
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- D-aspartate oxidase activity
- D-glutamate oxidase activity