DDO Gene Summary [Human]
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]
Details
| Type | Protein Coding |
| Official Symbol | DDO |
| Official Name | D-aspartate oxidase [Source:HGNC Symbol;Acc:HGNC:2727] |
| Ensembl ID | ENSG00000203797 |
| Bio databases IDs | |
| Aliases | D-aspartate oxidase |
| Synonyms | 5330420D20Rik, 5730402C02RIK, AI467244, DASOX, D-ASPARATE OXIDASE, D-aspartate oxidase, DASPO, DDO-1, DDO-2, LOC100911156, LOC682944 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- FAD dependent oxidoreductase
- enzyme
- protein binding
- D-aspartate oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- grooming behavior
- D-amino acid catabolic process
- regulation of cell communication
- insemination
- hormone metabolic process
- neurological system process
- aspartate catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytoplasm
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- D-aspartate oxidase activity
- D-glutamate oxidase activity