Cd59b Gene Summary [Mouse]
Predicted to enable complement binding activity. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in cell surface and plasma membrane. Is expressed in blood; heart; liver; lung; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd59b |
| Official Name | CD59b antigen [Source:MGI Symbol;Acc:MGI:1888996] |
| Ensembl ID | ENSMUSG00000068686 |
| Bio databases IDs | |
| Aliases | CD59b antigen |
| Synonyms | CD59b antigen |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd59b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hemolytic anemia
- hemosiderinuria
- anisopoikilocytosis
- oligozoospermia
- erythroblastosis
- necrospermia
- asthenozoospermia
- hemoglobinemia
- schistocytosis
- echinocytosis
regulated by
regulates
- MAC
- hemosiderin
- hemoglobin
role in cell
- cytolysis
- apoptosis
- cell viability
- function
- activation
- mobility
- quantity
- abnormal morphology
- number
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face
- myelin sheath
- sarcolemma