Pdia3 Gene Summary [Mouse]
Enables lncRNA binding activity. Acts upstream of or within cellular response to interleukin-7; platelet aggregation; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdia3 |
| Official Name | protein disulfide isomerase associated 3 [Source:MGI Symbol;Acc:MGI:95834] |
| Ensembl ID | ENSMUSG00000027248 |
| Bio databases IDs | |
| Aliases | protein disulfide isomerase associated 3 |
| Synonyms | ER60, Erp, ERp57, ERp60, ERp61, Glucose Regulated Protein, 58kd, GRP58, HEL-S-269, HEL-S-93n, Hs.308709, HsT17083, Microsomal CPT, Microsomal protease er-60, PDI, PDI-Q2, PHOSPHOLIPASE C alpha, PHOSPHOLIPASE C α, PI-PLC, Pi-plc 1, Plca, PLC[a], Protein disulfide isomerase, protein disulfide isomerase associated 3, protein disulfide isomerase family A member 3, protein disulfide isomerase family A, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdia3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- MHC class I protein binding
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Thioredoxin-like
- peptidase
- protein-disulfide reductase (glutathione)
- linker domain
- enzyme
- phospholipase C
- protein binding
- identical protein binding
- thioredoxin
- RNA binding
- disulfide oxidoreductase
- cysteine endopeptidase
- ER retention sequence
- protein disulfide isomerase, eukaryotic
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- a-type thioredoxin-like domain
- protein disulfide-isomerase domain
Pathways
Biological processes and signaling networks where the Pdia3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antigen Presentation Pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Lipid Antigen Presentation by CD1
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lung adenocarcinoma formation
- Alzheimer disease
- glioblastoma
- glioblastoma cancer
- lung adenocarcinoma
- rheumatoid arthritis
- colon epithelial cancer
- breast carcinoma
- survival
regulated by
- insulin
- Ca2+
- dexamethasone
- lipopolysaccharide
- Core
- hydrogen peroxide
- D-glucose
- P4HB
- 1,2-dithiole-3-thione
- beta-estradiol
role in cell
- apoptosis
- binding
- aggregation
- phosphorylation in
- expression in
- proliferation
- growth
- cell death
- generation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- myelin enriched fraction
- raft fractions
- insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- T granule
- endoplasmic reticulum lumen
- microsome
- apical membrane
- endosomal membrane
- nucleoli
- acrosome
- synaptic vesicles
- smooth endoplasmatic reticulum
- microsomal membrane
- phagosomes
- cis Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdia3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide antigen assembly with MHC class I protein complex
- extrinsic apoptotic signaling pathway
- adaptive immune response
- positive regulation of extrinsic apoptotic signaling pathway
- protein folding
- platelet aggregation
- response to endoplasmic reticulum stress
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- extracellular space
- MHC class I peptide loading complex
- extracellular vesicular exosome
- focal adhesion
- melanosome
- phagocytic vesicle
- endoplasmic reticulum
- recycling endosome membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- disulfide oxidoreductase activity
- protein disulfide isomerase activity
- protein disulfide oxidoreductase activity
- RNA binding
- protein binding
- phospholipase C activity
- cysteine-type endopeptidase activity