Muc3a Gene Summary [Mouse]
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | Muc3a |
| Official Name | mucin 3A, cell surface associated [Source:MGI Symbol;Acc:MGI:3588263] |
| Ensembl ID | ENSMUSG00000094840 |
| Bio databases IDs | |
| Aliases | mucin 3A, cell surface associated |
| Synonyms | A630081J09Rik, LOC100509522, LOC101060740, LOC102725120, LOC732156, MUC3, mucin 3A, cell surface associated |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SEA domain
- EGF_CA
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- neoplasia
- non-small cell lung cancer
- nasopharyngeal cancer
- epithelial cancer
- nasopharyngeal carcinoma
- organismal death
- non-small cell lung carcinoma
- sarcomatoid nasopharyngeal carcinoma
- sarcomatoid cancer
- mixed sarcomatoid-epithelial nasopharyngeal carcinoma
role in cell
- apoptosis
- expression in
- proliferation
- binding in
- damage in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi lumen
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc3a gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular matrix constituent, lubricant activity
- extracellular matrix structural constituent