Tsr2 Gene Summary [Rat]
The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | Tsr2 |
| Official Name | TSR2, ribosome maturation factor [Source:RGD Symbol;Acc:1562416] |
| Ensembl ID | ENSRNOG00000002556 |
| Bio databases IDs | |
| Aliases | TSR2, ribosome maturation factor |
| Synonyms | 2310007F12Rik, DBA14, DT1P1A10, NEWGENE 1562416, RGD1562416, TSR2 20S rRNA accumulation, TSR2 ribosome maturation factor, TSR2, ribosome maturation factor, WGG1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tsr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pre-rRNA-processing protein TSR2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tsr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding