Cradd

Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to mechanical stimulus; and positive regulation of apoptotic signaling pathway. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cradd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cradd gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.