Nlrp1a Gene Summary [Rat]
Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp1a |
| Official Name | NLR family, pyrin domain containing 1A [Source:RGD Symbol;Acc:1310963] |
| Ensembl ID | ENSRNOG00000023143 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 1A |
| Synonyms | LOC687763, Nalp1, NLR family, pyrin domain containing 1A, Nlrp1 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nlrp1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- NOD2 winged helix domain
- signaling receptor activity
- peptidase
- protein binding activity, bridging
- ATP binding
- enzyme binding
- protein domain specific binding
- enzyme regulator activity
- protein binding
- NACHT domain
- protease activator
- ATPase
- Caspase recruitment domain
- Function to find
- endopeptidase
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- double-stranded RNA binding
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Nlrp1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- lipopolysaccharide
- KH-3
regulates
- IL1B
- Inflammasome
role in cell
- activation in
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- perikaryon