Eppin Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Predicted to be located in acrosomal vesicle and cell surface. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eppin |
| Official Name | epididymal peptidase inhibitor [Source:RGD Symbol;Acc:1597722] |
| Ensembl ID | ENSRNOG00000028908 |
| Bio databases IDs | |
| Aliases | epididymal peptidase inhibitor |
| Synonyms | 1700024E17Rik, CT71, CT72, dJ461P17.2, epididymal peptidase inhibitor, LOC684712, SPINLW1, WAP7, WFDC7, Wfdc8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eppin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eppin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of calcium ion import
- defense response to bacterium
- negative regulation of peptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- acrosomal vesicle
- macromolecular complex
- cell surface
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding