Adam9 Gene Summary [Rat]
Predicted to enable several functions, including SH3 domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and protein kinase C binding activity. Involved in response to antineoplastic agent and response to laminar fluid shear stress. Located in basolateral plasma membrane and cell surface. Biomarker of Alzheimer's disease and status epilepticus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam9 |
| Official Name | ADAM metallopeptidase domain 9 [Source:RGD Symbol;Acc:621473] |
| Ensembl ID | ENSRNOG00000017231 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 9 |
| Synonyms | ADAM9 precursor, ADAM metallopeptidase domain 9, CORD9, MCMP, MDC9, meltrin gamma, meltrin γ, mKIAA0021, Mltng |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- disintegrin-cysteine-rich domain
- EGF_CA
- cytoplasmic domain
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- Collagen triple helix repeat (20 copies)
- tail domain
- Reprolysin family propeptide
- extracellular domain
- protein kinase C binding
- Pkc binding domain
- protein binding
- disintergrin domain
- SH3-domain binding
- metallopeptidase
- ZnMc
- laminin binding
- integrin binding
- transmembrane domain
- Disintegrin
- collagen binding
- Reprolysin (M12B) family zinc metalloprotease
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adam9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal cancer
- lung cancer
- retinal dystrophy
- cone-rod dystrophy type 9
- metastasis
- retinitis pigmentosa
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- squamous cell cancer of the oral cavity
- rheumatoid arthritis
role in cell
- activation
- adhesion
- expression in
- phosphorylation in
- migration
- differentiation
- proliferation
- motility
- quantity
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- cell-cell contacts
- plasma membrane extracellular face
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- response to manganese ion
- transforming growth factor beta receptor signaling pathway
- cell adhesion
- monocyte activation
- integrin-mediated signaling pathway
- positive regulation of membrane protein ectodomain proteolysis
- response to glucocorticoid stimulus
- cell-cell adhesion mediated by integrin
- positive regulation of keratinocyte migration
- positive regulation of cell adhesion mediated by integrin
- positive regulation of protein secretion
- cell migration
- cell-matrix adhesion
- membrane protein intracellular domain proteolysis
- positive regulation of macrophage fusion
- response to hydrogen peroxide
- keratinocyte differentiation
- cell adhesion mediated by integrin
- response to laminar fluid shear stress
- cellular response to lipopolysaccharide
- membrane protein ectodomain proteolysis
- response to calcium ion
- response to tumor necrosis factor
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- external side of plasma membrane
- basolateral plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- collagen binding
- metal ion binding
- integrin binding
- SH3 domain binding
- metalloendopeptidase activity
- laminin binding
- metallopeptidase activity