Gpr68 Gene Summary [Rat]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cellular response to pH. Predicted to act upstream of or within negative regulation of monocyte differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of osteoclast development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr68 |
| Official Name | G protein-coupled receptor 68 [Source:RGD Symbol;Acc:1309559] |
| Ensembl ID | ENSRNOG00000046309 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 68 |
| Synonyms | AI2A6, GPR12A, G protein-coupled receptor 68, LOC100909523, OGR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpr68 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr68 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- medulloblastoma SHH subtype
- brain cancer
- HER2 negative hormone receptor negative breast cancer
- amelogenesis imperfecta
- luminal breast cancer
- HER2-positive breast cancer
- hypomaturation type amelogenesis imperfecta IIA6
role in cell
- activation in
- phosphorylation in
- expression in
- formation
- formation in
- growth
- number
- cell death
- autophagy in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpr68 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast development
- inflammatory response
- insulin secretion
- G-protein coupled receptor signaling pathway
- positive regulation of osteoclast development
- cellular response to pH
- monocyte differentiation
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- negative regulation of monocyte differentiation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity