Ptgs2 Gene Summary [Rat]
Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgs2 |
| Official Name | prostaglandin-endoperoxide synthase 2 [Source:RGD Symbol;Acc:620349] |
| Ensembl ID | ENSRNOG00000002525 |
| Bio databases IDs | |
| Aliases | prostaglandin-endoperoxide synthase 2 |
| Synonyms | Cox, COX-2, CYCLO-OXYGENASE 2, GRIPGHS, hCox-2, hnCOX-2, INDUCIBLE CYCLOOXYGENASE, PES-2, PGG/HS, PGHS-2, PGH synthase 2, Pgi2 synthase, Pgs2, Pgsi, PHS-2, PHS II, Prostaglandin endoperoxide synthase 2, TIS10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptgs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclooxygenase
- enzyme binding
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
- protein binding
- heme binding
- EGF_CA
- peroxidase
- protein homodimerization
- tail domain
- single donor 2 atom incorporation:oxygen oxidoreductase
- paired donor oxygen oxidoreductase
- single donor oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Ptgs2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Cancer Drug Resistance By Drug Efflux
- CD40 Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-8 Signaling
- ILK Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- PPAR Signaling
- Role of IL-17A in Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of Tissue Factor in Cancer
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- ovarian cancer
- diarrhea
- infection
- plasma cell myeloma
- chronic obstructive pulmonary disease
- otitis media
- urolithiasis
regulated by
- NADPH
- cholesterol
- CYP7A1
- tetradecanoylphorbol acetate
- PD98059
- curcumin
- indomethacin
- NS-398
- bisindolylmaleimide I
- resolvin D1
role in cell
- cell death
- induction in
- necrosis
- differentiation
- survival
- expression in
- proliferation
- apoptosis
- growth
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- soluble fraction
- membrane fraction
- lipid-rich fraction
- intracellular membrane-bounded organelle
- perinuclear membrane
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- intercellular junctions
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- caveolae
- inner nuclear membrane
- perinuclear space
- outer nuclear membrane
- nuclear envelope
- dendritic spines
- neurites
- dendritic trees
- rough endoplasmatic reticulum
- microsomal membrane
- perikaryon
- dendrites
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptgs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of brown fat cell differentiation
- response to fructose stimulus
- decidualization
- learning
- positive regulation of cell migration involved in sprouting angiogenesis
- memory
- brown fat cell differentiation
- cellular response to fluid shear stress
- positive regulation of synaptic plasticity
- negative regulation of calcium ion transport
- positive regulation of synaptic transmission, glutamatergic
- cellular response to hypoxia
- maintenance of blood-brain barrier
- positive regulation vascular endothelial growth factor production
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of protein import into nucleus
- positive regulation of prostaglandin biosynthetic process
- cellular response to lead ion
- prostaglandin biosynthetic process
- response to estradiol stimulus
- regulation of inflammatory response
- prostaglandin secretion
- positive regulation of fever generation
- response to tumor necrosis factor
- response to manganese ion
- positive regulation of nitric oxide biosynthetic process
- response to vitamin D
- negative regulation of cell proliferation
- positive regulation of vasoconstriction
- negative regulation of cell cycle
- response to xenobiotic stimulus
- positive regulation of fibroblast growth factor production
- hair cycle
- negative regulation of smooth muscle contraction
- positive regulation of smooth muscle contraction
- positive regulation of smooth muscle cell proliferation
- cellular response to non-ionic osmotic stress
- response to oxidative stress
- cellular response to heat
- angiogenesis
- response to glucocorticoid stimulus
- response to fatty acid
- cellular response to ATP
- negative regulation of synaptic transmission, dopaminergic
- positive regulation of transforming growth factor beta production
- bone mineralization
- positive regulation of platelet-derived growth factor production
- regulation of blood pressure
- response to nematode
- embryo implantation
- cellular response to mechanical stimulus
- cyclooxygenase pathway
- positive regulation of apoptotic process
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nuclear inner membrane
- caveola
- cytoplasm
- macromolecular complex
- endoplasmic reticulum
- nuclear outer membrane
- neuron projection
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- prostaglandin-endoperoxide synthase activity
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- protein binding
- protein homodimerization activity
- metal ion binding
- heme binding
- enzyme binding