Tnfsf11 Gene Summary [Rat]
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf11 |
| Official Name | TNF superfamily member 11 [Source:RGD Symbol;Acc:620784] |
| Ensembl ID | ENSRNOG00000049547 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 11 |
| Synonyms | CD254, hRANKL2, LOC103689974, Ly109l, ODF, OPGL, OPTB2, RANKL, Rankl1, sOdf, TNF superfamily member 11, TNLG6B, TRANCE, tumor necrosis factor (ligand) superfamily, member 11, tumour necrosis factor (ligand) superfamily, member 11, tumour necrosis factor related activation induced cytokine |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfsf11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- TNF
- ectodomain
- protein binding
- cytokine
- identical protein binding
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- receptor binding domain
- cytoplasmic domain
- transmembrane domain
- receptor agonist activity
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Tnfsf11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- NF-κB Signaling
- RANK Signaling in Osteoclasts
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HIV infection
- metastasis
- infection
- pain
- cancer
- nodal marginal zone lymphoma
- chronic lymphocytic leukemia / small lymphocytic lymphoma
- extranodal marginal zone cell lymphoma
- osteopenia
role in cell
- phosphorylation in
- proliferation
- production in
- expression in
- induction in
- invasion by
- cell death
- cell viability
- degradation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfsf11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- osteoclast development
- calcium ion homeostasis
- positive regulation of homotypic cell-cell adhesion
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of transcription from RNA polymerase II promoter
- osteoclast proliferation
- positive regulation of corticotropin-releasing hormone secretion
- protein kinase B signaling cascade
- positive regulation of T cell activation
- immune response
- positive regulation of osteoclast differentiation
- mammary gland alveolus development
- bone resorption
- ossification
- cytokine-mediated signaling pathway
- mammary gland epithelial cell proliferation
- positive regulation of osteoclast development
- calcium-mediated signaling
- positive regulation of fever generation by positive regulation of prostaglandin secretion
- paracrine signaling
- ERK1 and ERK2 cascade
- osteoclast differentiation
- tumor necrosis factor-mediated signaling pathway
- monocyte chemotaxis
- positive regulation of bone resorption
- positive regulation of JNK cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- tumor necrosis factor receptor superfamily binding
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity