Cyp4f4 Gene Summary [Rat]
Enables arachidonate monooxygenase activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in icosanoid catabolic process; omega-hydroxylase P450 pathway; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertrophic cardiomyopathy. Orthologous to human CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp4f4 |
| Official Name | cytochrome P450, family 4, subfamily f, polypeptide 4 [Source:RGD Symbol;Acc:708363] |
| Ensembl ID | ENSRNOG00000032895 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 4, subfamily f, polypeptide 4 |
| Synonyms | Cyp4f4, cytochrome P450, family 4, subfamily f, polypeptide 15, cytochrome P450, family 4, subfamily f, polypeptide 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp4f4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- fatty acid binding
- leukotriene-B4 20-monooxygenase
- enzyme
- heme binding
- arachidonic acid epoxygenase
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
- alkane 1-monooxygenase
- arachidonic acid monooxygenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- intracellular membrane-bounded organelle
- Cytoplasm
- endoplasmic reticulum membrane
- apical membrane