Smarcb1 Gene Summary [Rat]
Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; positive regulation by host of viral transcription; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including blastocyst hatching; hepatocyte differentiation; and single stranded viral RNA replication via double stranded DNA intermediate. Located in chromatin. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; meningioma; rhabdoid cancer; rhabdoid tumor predisposition syndrome 1; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarcb1 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [Source:RGD Symbol;Acc:1308761] |
| Ensembl ID | ENSRNOG00000028302 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
| Synonyms | BAF47, CSS3, hSNFS, INI1, LOC103694876, MRD15, PPP1R144, RDT, RTPS1, Sfh1p, SMARB1, SNF5, SNF5/INI1, SNF5L1, Snr1, SWI/SNF related BAF chromatin remodeling complex subunit B1, SWNTS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smarcb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- nuclear export signal
- WH_NTD_SMARCB1_like
- Ini1/SNF5 binding domain
- INI1 repeat domain
- nucleic acid binding
- SNF5 homology domain
- transcription factor binding
- coiled-coil domain
- p53 binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- integrase binding domain
- DNA binding
- repeat 2 domain
- repeat 1 domain
- double-stranded DNA binding
- SNF5 / SMARCB1 / INI1
Pathways
Biological processes and signaling networks where the Smarcb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- Burkitt lymphoma
- schwannomatosis type 1
- hereditary cancer-predisposing syndrome
- autosomal dominant mental retardation type 15
- rhabdoid tumor
- rhabdoid cancer
- dementia
- conventional mantle cell lymphoma
role in cell
- apoptosis
- colony formation
- cell viability
- survival
- cell survival
- migration
- expression in
- activation in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear matrix fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- nucleoli
- sex chromatin
- endocytotic vesicle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smarcb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- regulation of mitotic metaphase/anaphase transition
- positive regulation of gene expression, epigenetic
- negative regulation of cell proliferation
- nervous system development
- DNA integration
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- RNA polymerase I transcriptional preinitiation complex assembly
- chromatin remodeling
- hepatocyte differentiation
- positive regulation of T cell differentiation
- blastocyst hatching
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nuclear chromosome
- brahma complex
- kinetochore
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
- XY body
- nucleus
- germ cell nucleus
- npBAF complex
- intracellular membrane-bounded organelle
- nuclear matrix
- macromolecular complex
- nBAF complex
- RSC complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- p53 binding
- RNA polymerase I CORE element sequence-specific DNA binding
- protein binding
- transcription coactivator activity
- Tat protein binding
- nucleosomal DNA binding