Slc6a4 Gene Summary [Rat]
Enables several functions, including cocaine binding activity; monoatomic cation transmembrane transporter activity; and syntaxin-1 binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to cGMP; and learning or memory. Located in endomembrane system and plasma membrane. Is active in postsynaptic membrane; presynaptic membrane; and serotonergic synapse. Used to study anxiety disorder; depressive disorder; and pulmonary hypertension. Biomarker of Parkinsonism; borna disease; congenital diaphragmatic hernia; and fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a4 |
| Official Name | solute carrier family 6 member 4 [Source:RGD Symbol;Acc:3714] |
| Ensembl ID | ENSRNOG00000003476 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 member 4 |
| Synonyms | 5-HTT, 5-HTTLPR, 5-HT TRANSPORTER, hSERT, HTT, OCD1, Serotonin Transporter, SERT, SERT1, solute carrier family 6 member 4, SOLUTE CARRIER family 6, member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc6a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serotonin:sodium symporter
- Serotonin (5-HT) neurotransmitter transporter, N-terminus
- Sodium:neurotransmitter symporter family
- serotonin binding
- metal ion binding
- enzyme binding
- cocaine binding
- neurotransmitter transporter
- protein binding
- identical protein binding
- actin filament binding
- monoamine transporter
- syntaxin-1 binding
- integrin binding
- transmembrane domain
- antiporter
- intracellular domain
- extracellular loop
- Solute carrier families 5 and 6-like; solute binding domain
- cation channel
- transporter
Pathways
Biological processes and signaling networks where the Slc6a4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- cancer
- pain
- chemotherapy sickness
- hyperplasia
- allergy
- atopic dermatitis
- chronic interstitial cystitis
- allergic rhinitis
- urticaria
regulated by
- 5-hydroxytryptamine
- insulin
- dexamethasone
- lipopolysaccharide
- beta-estradiol
- citalopram
- SNCA
- 5-N-ethylcarboxamido adenosine
- chloride
- Na+
role in cell
- expression in
- activation in
- phosphorylation in
- survival
- number
- quantity
- proliferation
- activity
- cell cycle progression
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- endomembrane system
- ganglioside GM1 enriched microdomain
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- focal adhesions
- apical cell surfaces
- presynaptic membrane
- postsynaptic membrane
- axon arbors
- nerve ending
- synaptosomes
- synapse
- membrane rafts
- cellular protrusions
- perikaryon
- axons
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc6a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm ejaculation
- positive regulation of serotonin secretion
- negative regulation of neuron differentiation
- positive regulation of cell cycle
- vasoconstriction
- brain morphogenesis
- response to xenobiotic stimulus
- memory
- amino acid transport
- response to toxin
- enteric nervous system development
- neurotransmitter transport
- response to hypoxia
- behavioral response to cocaine
- negative regulation of synaptic transmission, dopaminergic
- monoamine transport
- platelet aggregation
- social behavior
- regulation of thalamus size
- negative regulation of cerebellar granule cell precursor proliferation
- response to nutrient
- negative regulation of organ growth
- circadian rhythm
- serotonin uptake
- cellular response to cGMP
- cellular response to retinoic acid
- positive regulation of gene expression
- response to estradiol stimulus
- sodium ion transmembrane transport
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- focal adhesion
- postsynaptic membrane
- membrane raft
- endomembrane system
- endosome membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- antiporter activity
- cation channel activity
- integrin binding
- monoamine transmembrane transporter activity
- serotonin:sodium symporter activity
- serotonin binding
- actin filament binding
- neurotransmitter transporter activity
- protein binding
- syntaxin-1 binding
- sodium ion binding
- nitric-oxide synthase binding
- cocaine binding